Dosing in EPI Patients Without CF

Looking for dosing in patients with CF?

For patients with EPI,

Only ZENPEP® lets you start most adults on a single capsule1,2

A chart recommending the recommended weight-based dosing for adults with EPI along with the average weight of American males and females.A chart recommending the recommended weight-based dosing for adults with EPI along with the average weight of American males and females.
Capsules not actual size.
  • The dose of ZENPEP should be individualized based on weight, severity of clinical symptoms, the degree of steatorrhea present, and the fat contents of the patient’s diet1
  • For patients on the lower end of the weight range, a lower dose may be appropriate
  • This chart is intended to be an example; ZENPEP capsules represent nearest capsule count within recommended dosing range
  • Do not exceed 2,500 lipase units/kg/meal, 10,000 lipase units/kg/day, or 4,000 lipase units/g fat ingested/day in adult and pediatric patients greater than 12 months of age without further investigation.1
Titration steps based on symptoms and fat intakeTitration steps based on symptoms and fat intake

*For severe EPI with steatorrhea, write 2 capsules PO with each meal. Dispense 300.

ZENPEP capsules and capsule contents should not be crushed or chewed. 
ZENPEP should be taken with every meal and snack. Usually, half of the prescribed dose for an individualized full meal should be given with each snack.1 
Therapy should be initiated at the lowest recommended dosage and individualize the dosage based on clinical symptoms, the degree of steatorrhea present, and the fat content of the diet.

Meets the ACG guideline for EPI and CP in a single capsule.†

For patients with EPI and CP, the ACG-recommended adequate dosage of PERT is at least 40,000 to 50,000 lipase units per meal.3

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References: 1. ZENPEP. Package insert. Aimmune Therapeutics, Inc. Bridgewater, NJ; October 2024. 2. Fryar CD, Carroll MD, Gu Q, Afful J, Ogden CL. Anthropometric reference data for children and adults: United States, 2015–2018. National Center for Health Statistics. Vital Health Stat. 2021;3(46):1-44. 3. Gardner TB, Adler DG, Forsmark CE, Sauer BG, Taylor JR, Whitcomb DC. ACG Clinical Guideline: chronic pancreatitis. Am J Gastroenterol. 2020;115(3):322-339. doi:10.14309/ajg.0000000000000535